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Phenotypes Associated with This Genotype
Genotype
MGI:6515759
Allelic
Composition		 Albtm1(cre/ERT2)Mtz/Alb+
Polr2mtm1.1Rgr/Polr2mtm1.1Rgr
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Albtm1(cre/ERT2)Mtz mutation (1 available); any Alb mutation (91 available)
Polr2mtm1.1Rgr mutation (0 available); any Polr2m mutation (20 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
increased hepatocyte karyomegaly ( J:291184 )
• following tamoxifen injection, nuclei are enlarged compared to cells from Trp53 null mice
increased hepatocyte proliferation ( J:291184 )
• expression analysis indicates hepatocytes rapidly reenter the cell cycle after tamoxifen treatment

cellular
increased hepatocyte karyomegaly ( J:291184 )
• following tamoxifen injection, nuclei are enlarged compared to cells from Trp53 null mice
increased hepatocyte proliferation ( J:291184 )
• expression analysis indicates hepatocytes rapidly reenter the cell cycle after tamoxifen treatment

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory