Phenotypes Associated with This Genotype

Genotype
MGI:6505548

• Allelic Composition: Kras^tm1.1Khai/Kras⁺; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:276349 )

• pIpC-induced mice die prematurely but at an older age than induced conditional Kras^tm4Tyj mice

hematopoietic system

abnormal hematopoietic system morphology/development ( J:276349 )

• mice induced with polyinosinic:polycytidylic acid (pIpC) develop a myelodysplastic syndrome/myeloproliferative neoplasm that is qualitatively similar to that seen in conditional Kras^tm4Tyj mice, but with a delayed onset

enlarged spleen ( J:276349 )

• dying pIpC-induced mice show splenomegaly

anemia ( J:276349 )

• dying pIpC-induced mice show severe anemia

decreased hemoglobin content ( J:276349 )

• hemoglobin levels decline over time in pIpC-induced mice

increased leukocyte cell number ( J:276349 )

• white blood cell counts slowly rise over time in pIpC-induced mice

increased myeloid cell number ( J:276349 )

• expansion of immature myeloid cells in the bone marrow and spleen in pIpC-induced mice

increased myeloid cell number in bone marrow ( J:276349 )

• expansion of immature myeloid cells in the bone marrow of pIpC-induced mice

immune system

enlarged spleen ( J:276349 )

• dying pIpC-induced mice show splenomegaly

increased leukocyte cell number ( J:276349 )

• white blood cell counts slowly rise over time in pIpC-induced mice

growth/size/body

enlarged spleen ( J:276349 )

• dying pIpC-induced mice show splenomegaly