Phenotypes Associated with This Genotype

Genotype
MGI:6477405

• Allelic Composition: Trp63^tm2.1Aam/Trp63^tm3Aam
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

cleft palate ( J:294158 )

• 95% of neonates exhibit cleft palate

digestive/alimentary system

cleft palate ( J:294158 )

• 95% of neonates exhibit cleft palate

growth/size/body

cleft palate ( J:294158 )

• 95% of neonates exhibit cleft palate

integument

thick dermal layer ( J:294158 )

• dermis is thicker in large areas of the skin

abnormal epidermal layer morphology ( J:294158 )

• epidermis is abnormal with the stratum basale and stratum spinosum affected; thickening of Trp63-, K14-, and K10-expressing layers in patches of the epidermis covering the skin surface

thick epidermis stratum basale ( J:294158 )

thick epidermis stratum spinosum ( J:294158 )

limbs/digits/tail

abnormal limb morphology ( J:294158 )

• 100% of neonates exhibit limb defects, ranging from lack of hindlimbs to single ectrodactyly

ectrodactyly ( J:294158 )

• single ectrodactyly in some neonates