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Phenotypes Associated with This Genotype
Genotype
MGI:6403693
Allelic
Composition		 Hprt1tm1(CAG-BRF1)Gu/Hprt1+
Krastm4Tyj/Kras+
Trp53tm2Tyj/Trp53+
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(CAG-BRF1)Gu mutation (0 available); any Hprt1 mutation (1280 available)
Krastm4Tyj mutation (11 available); any Kras mutation (69 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53tm2Tyj mutation (2 available); any Trp53 mutation (237 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:285667 )
• as in mice lacking the BRF1 knock-in

neoplasm
increased pancreatic ductal adenocarcinoma incidence ( J:285667 )
• as in mice lacking the BRF1 knock-in

homeostasis/metabolism
abnormal translation ( J:285667 )
• tRNA levels are increased in the pancreas

endocrine/exocrine glands
increased pancreatic ductal adenocarcinoma incidence ( J:285667 )
• as in mice lacking the BRF1 knock-in

cellular
abnormal translation ( J:285667 )
• tRNA levels are increased in the pancreas

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory