Phenotypes for Brf1 Kras Tg(Pdx1-cre)6Tuv Trp53 MGI:6403690 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Brf1^tm1Arte/Brf1^tm1Arte Kras^tm4Tyj/Kras⁺ Trp53^tm2Tyj/Trp53⁺ Tg(Pdx1-cre)6Tuv/0
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brf1^tm1Arte mutation (0 available); any Brf1 mutation (24 available)
Kras^tm4Tyj mutation (11 available); any Kras mutation (69 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53^tm2Tyj mutation (2 available); any Trp53 mutation (237 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:285667 )

• extended survival compared to control mice with normal Brf1

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:285667 )

• at a reduced rate and with extended survival compared to control mice with normal Brf1

• however, tumors that do form lack recombined Brf1

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:285667 )

• at a reduced rate and with extended survival compared to control mice with normal Brf1

• however, tumors that do form lack recombined Brf1

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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