Phenotypes Associated with This Genotype

Genotype
MGI:6403636

• Allelic Composition: Tg(DPP4)2Nnag/0; Tmprss2^{tm1(KOMP)Vlcg}/Tmprss2^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NCr * C57BL/6NTac * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal cytokine secretion ( J:283077 )

• MERS-CoV-infected mice show a delay in and less pronounced chemokine and cytokine responses, with decreased concentrations of FGF-basic, GM-CSF, MIG/CXCL9, and TNF-alpha but increased levels of IL-6 and other inflammatory cytokines like MIP-1alpha, IL-1alpha and IL-1beta

decreased susceptibility to Coronaviridae infection ( J:283077 )

• mice show decreased susceptibility to infection with the EMC2012 strain of the Middle East respiratory syndrome coronavirus (MERS-CoV) , with no or only a slight weight loss, slower viral replication in the lungs, lower titers of neutralizing antibodies in sera, and less severe lung pathology with only mild mononuclear cell infiltration of the alveoli by 7 days post infection compared to single Tg(DPP4)2Nnag mice