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Phenotypes Associated with This Genotype
Genotype
MGI:6384016
Allelic
Composition		 Ptentm1Hwu/Ptentm1Hwu
Ptpn11tm1Gsf/Ptpn11tm1Gsf
Tg(Six3-cre)69Frty/0
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (17 available); any Pten mutation (87 available)
Ptpn11tm1Gsf mutation (0 available); any Ptpn11 mutation (44 available)
Tg(Six3-cre)69Frty mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
retina ganglion cell degeneration ( J:174095 )
• much thinner at age P21
optic nerve atrophy ( J:174095 )
• much thinner at age P21
thin retina ganglion layer ( J:174095 )
• severe reduction at age P21
thin retina inner nuclear layer ( J:174095 )
• severe reduction at age P21
thin retina outer nuclear layer ( J:174095 )
• severe reduction at age P21
retina outer nuclear layer degeneration ( J:174095 )
• much thinner at age P21
retina degeneration ( J:174095 )
• much thinner at age P21

nervous system
retina ganglion cell degeneration ( J:174095 )
• much thinner at age P21
optic nerve atrophy ( J:174095 )
• much thinner at age P21

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory