Phenotypes for Pten Ptpn11 Tg(Six3-cre)69Frty MGI:6384016 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Pten^tm1Hwu/Pten^tm1Hwu Ptpn11^tm1Gsf/Ptpn11^tm1Gsf Tg(Six3-cre)69Frty/0
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1Hwu mutation (17 available); any Pten mutation (86 available)
Ptpn11^tm1Gsf mutation (0 available); any Ptpn11 mutation (43 available)
Tg(Six3-cre)69Frty mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

retina ganglion cell degeneration ( J:174095 )

• much thinner at age P21

optic nerve atrophy ( J:174095 )

• much thinner at age P21

thin retina ganglion layer ( J:174095 )

• severe reduction at age P21

thin retina inner nuclear layer ( J:174095 )

• severe reduction at age P21

thin retina outer nuclear layer ( J:174095 )

• severe reduction at age P21

retina outer nuclear layer degeneration ( J:174095 )

• much thinner at age P21

retina degeneration ( J:174095 )

• much thinner at age P21

nervous system

retina ganglion cell degeneration ( J:174095 )

• much thinner at age P21

optic nerve atrophy ( J:174095 )

• much thinner at age P21

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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