Phenotypes Associated with This Genotype

Genotype
MGI:6357744

• Allelic Composition: Atp6ap2^tm1.1Aich/Atp6ap2^tm1.1Aich; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

enlarged liver ( J:274386 )

♀ • mice treated with polyinosinic-polycytidylic acid [poly(I:C)] for 5 days to induce cre-expression exhibit livers enlarged by 60%

abnormal hepatocyte morphology ( J:274386 )

♀ • hepatocytes are hypertrophic in poly(I:C)-treated mice

♀ • hepatocytes of poly(I:C)-treated mice show massive accumulation of endocytic and autophagic vacuoles

abnormal hepatocyte physiology ( J:274386 )

♀ • cultured hepatocytes from poly(I:C)-treated mice show decreased autophagic clearance

♀ • however, hepatocytes show normal acidification and delivery of endocytic cargo to lysosomes and autolysosomes

cellular

impaired autophagy ( J:274386 )

♀ • cultured hepatocytes from poly(I:C)-treated mice show decreased autophagic clearance

homeostasis/metabolism

impaired autophagy ( J:274386 )

♀ • cultured hepatocytes from poly(I:C)-treated mice show decreased autophagic clearance

growth/size/body

enlarged liver ( J:274386 )

♀ • mice treated with polyinosinic-polycytidylic acid [poly(I:C)] for 5 days to induce cre-expression exhibit livers enlarged by 60%