Phenotypes for Apc Mapkapk2 Tg(Tie1-cre)9Ref MGI:6357721 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Apc^Min/Apc⁺ Mapkapk2^tm1.1Gkl/Mapkapk2^tm1.1Gkl Tg(Tie1-cre)9Ref/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (151 available)
Mapkapk2^tm1.1Gkl mutation (1 available); any Mapkapk2 mutation (35 available)
Tg(Tie1-cre)9Ref mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor cell death ( J:262876 )

• increased apoptosis of tumor cells compared to in Apc^min heterozygotes

decreased tumor cell proliferation ( J:262876 )

• reduced proliferation of tumor cells compared to in Apc^min heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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