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Phenotypes Associated with This Genotype
Genotype
MGI:6317330
Allelic
Composition		 Mirc1tm1.1Tyj/Mirc1tm1.1Tyj
Pkd2tm3Som/Pkd2tm3Som
Tg(Pkhd1-cre)1Igr/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.1Tyj mutation (2 available); any Mirc1 mutation (7 available)
Pkd2tm3Som mutation (0 available); any Pkd2 mutation (84 available)
Tg(Pkhd1-cre)1Igr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:244067 )
• mice have a median survival of 127 days which is 149% increase in median survival compared to single conditional Pkd2 mutants

renal/urinary system
decreased kidney cell proliferation ( J:244067 )
• mice show a 58.9% decrease in the number of proliferating cyst epithelial cells compared to single conditional Pkd2 mutants
kidney cyst ( J:244067 )
• mice show a 15.8% reduction in cyst index compared to single conditional Pkd2 mutants

cellular
decreased kidney cell proliferation ( J:244067 )
• mice show a 58.9% decrease in the number of proliferating cyst epithelial cells compared to single conditional Pkd2 mutants

homeostasis/metabolism
decreased circulating creatinine level ( J:244067 )
• mice show a 31.8% improvement in serum creatinine levels compared to single conditional Pkd2 mutants

growth/size/body
kidney cyst ( J:244067 )
• mice show a 15.8% reduction in cyst index compared to single conditional Pkd2 mutants

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory