Phenotypes Associated with This Genotype

Genotype
MGI:6306137

• Allelic Composition: Tg(Col2a1-cre/ERT2)1Dic/0; Tgfbr1^tm1.1Karl/Tgfbr1^tm1.1Karl
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

osteoarthritis ( J:271724 )

• tamoxifen-treated mice exhibit progressive degeneration and lesions of the knee articular cartilage from 2-6 months of age

• lesions exhibit as either empty lacuna or confined loss of cartilage tissue

• 3 month old tamoxifen-treated mice show an early osteoarthritis-like phenotype, including loss of proteoglycan content and cartilage tissue and increased number of hypertrophic chondrocytes in articular cartilage

• 6 month old tamoxifen-treated mice exhibit more severe destruction of the articular cartilage, associated with greater loss of proteoglycan content and cartilage, osteophyte formation and increased subchondral bone mass

skeleton

increased chondrocyte apoptosis ( J:271724 )

• tamoxifen-treated mice exhibit increased articular chondrocyte apoptosis

osteoarthritis ( J:271724 )

• tamoxifen-treated mice exhibit progressive degeneration and lesions of the knee articular cartilage from 2-6 months of age

• lesions exhibit as either empty lacuna or confined loss of cartilage tissue

• 3 month old tamoxifen-treated mice show an early osteoarthritis-like phenotype, including loss of proteoglycan content and cartilage tissue and increased number of hypertrophic chondrocytes in articular cartilage

• 6 month old tamoxifen-treated mice exhibit more severe destruction of the articular cartilage, associated with greater loss of proteoglycan content and cartilage, osteophyte formation and increased subchondral bone mass

osteophytes ( J:271724 )

• osteophyte formation is seen in 6 month old tamoxifen-treated mice

abnormal synovial joint morphology ( J:271724 )

• tamoxifen-treated mice exhibit synovial hyperplasia

abnormal articular cartilage morphology ( J:271724 )

• tamoxifen-treated mice show increased articular cartilage thickness at 2 months of age with zonal disruption and loss of proteoglycan content

cellular

increased chondrocyte apoptosis ( J:271724 )

• tamoxifen-treated mice exhibit increased articular chondrocyte apoptosis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
osteoarthritis		DOID:8398		J:271724