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Phenotypes Associated with This Genotype
Genotype
MGI:6296753
Allelic
Composition
Atg16l1tm1Kuv/Atg16l1tm1Kuv
Tg(Vil1-cre)997Gum/0
Genetic
Background
B6.Cg-Atg16l1tm1Kuv Tg(Vil1-cre)997Gum
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg16l1tm1Kuv mutation (1 available); any Atg16l1 mutation (44 available)
Tg(Vil1-cre)997Gum mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• in the ileum of DSS-treated mice exacerbated by IL22 treatment
• however, co-treatment with anti-IFNAR antibodies reduces the crypt region cell death under hard DSS treatment plus IL22
• organoid cell death induced by IFNbeta is amplified
• under a harsh DSS treatment regime, mice exhibit increased inflammatory regardless of anti-IFNAR treatment compared with control mice
• however, severity of colonic inflammation is not exacerbated by IL22 treatment
• under mild or harsh DSS treatment regimes, mice exhibit increased ileal inflammation exacerbated by IL22 treatment compared with control mice
• however, co-treatment with anti-IFNAR antibodies reduces the severity of small intestinal inflammation under hard DSS treatment plus IL22

growth/size/body
• in mice treated with IL22 and DSS

immune system
• under a harsh DSS treatment regime, mice exhibit increased inflammatory regardless of anti-IFNAR treatment compared with control mice
• however, severity of colonic inflammation is not exacerbated by IL22 treatment
• under mild or harsh DSS treatment regimes, mice exhibit increased ileal inflammation exacerbated by IL22 treatment compared with control mice
• however, co-treatment with anti-IFNAR antibodies reduces the severity of small intestinal inflammation under hard DSS treatment plus IL22

cellular
• in the ileum of DSS-treated mice exacerbated by IL22 treatment
• however, co-treatment with anti-IFNAR antibodies reduces the crypt region cell death under hard DSS treatment plus IL22
• organoid cell death induced by IFNbeta is amplified


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory