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Phenotypes Associated with This Genotype
Genotype
MGI:6296002
Allelic
Composition		 Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Krastm4Tyj/Kras+
Tg(Pdx1-cre)6Tuv/0
Trp53tm2Tyj/Trp53+
Genetic
Background		 involves: 129 * C57BL/6NCrl * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm9(CAG-tdTomato)Hze mutation (7 available); any Gt(ROSA)26Sor mutation (1095 available)
Krastm4Tyj mutation (12 available); any Kras mutation (88 available)
Tg(Pdx1-cre)6Tuv mutation (4 available)
Trp53tm2Tyj mutation (4 available); any Trp53 mutation (249 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased pancreatic ductal adenocarcinoma incidence ( J:245611 )
• pancreas contains PanINs and adenocarcinoma
increased pancreatic intraepithelial neoplasia incidence ( J:245611 )
• pancreas contains PanINs and adenocarcinoma

neoplasm
increased pancreatic ductal adenocarcinoma incidence ( J:245611 )
• pancreas contains PanINs and adenocarcinoma
increased pancreatic intraepithelial neoplasia incidence ( J:245611 )
• pancreas contains PanINs and adenocarcinoma
increased metastatic potential ( J:245611 )
• most mice develop metastases which are numerous and widespread in many different sites, including the lymph nodes, diaphragm, lungs, and liver
• all mice exhibit peritoneal disseminated tumor cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory