Phenotypes for Dnmt3a Tg(Mx1-cre)1Cgn MGI:6286132 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Dnmt3a^tm1Trow/Dnmt3a⁺ Tg(Mx1-cre)1Cgn/0
Genetic Background	B6.Cg-Dnmt3a^tm1Trow Tg(Mx1-cre)1Cgn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt3a^tm1Trow mutation (1 available); any Dnmt3a mutation (139 available)
Tg(Mx1-cre)1Cgn mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal multipotent stem cell morphology ( J:272803 )

• 6 months after induction with poly(I:C) (pIpC), multipotent progenitor cell populations increase in percentage and total number in bone marrow

hematopoietic system

increased common myeloid progenitor cell number ( J:272803 )

• 6 months after induction with poly(I:C) (pIpC), multi-lineage, mixed granulocyte/erythroid/macrophage/megakaryocyte (GEMM) colonies increase in percentage and total number in bone marrow

abnormal bone marrow hematopoietic cell morphology ( J:272803 )

increased hematopoietic stem cell number ( J:272803 )

• 6 months after induction with poly(I:C) (pIpC), viable long term hematopoietic stem cells and short term hematopoietic stem cells increase in percentage and total number in bone marrow

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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