Phenotypes Associated with This Genotype

Genotype
MGI:6284773

• Allelic Composition: Snrk^tm1.1Hxu/Snrk^tm1.1Hxu; Tg(Adipoq-cre)1Evdr/0
• Genetic Background: B6.Cg-Snrk^tm1.1Hxu Tg(Adipoq-cre)1Evdr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal adipose tissue distribution ( J:257980 )

• infiltration of adipocytes between muscle fibers

decreased fat cell size ( J:257980 )

brown adipose tissue inflammation ( J:257980 )

• macrophage accumulation in BAT

white adipose tissue inflammation ( J:257980 )

• macrophage accumulation in WAT

growth/size/body

increased body weight ( J:257980 )

homeostasis/metabolism

increased circulating free fatty acids level ( J:257980 )

• plasma FFA and triglyceride levels are elevated

increased circulating triglyceride level ( J:257980 )

• plasma FFA and triglyceride levels are elevated

abnormal circulating chemokine level ( J:257980 )

• plasma levels of cytokines and chemokines are increased - TNF, IL6, MCP1, MCP2, MCP3

increased circulating interleukin-6 level ( J:257980 )

increased circulating tumor necrosis factor level ( J:257980 )

decreased core body temperature ( J:257980 )

decreased energy expenditure ( J:257980 )

impaired glucose tolerance ( J:257980 )

insulin resistance ( J:257980 )

liver/biliary system

hepatic steatosis ( J:257980 )

• increased lipid accumulation in liver

immune system

brown adipose tissue inflammation ( J:257980 )

• macrophage accumulation in BAT

white adipose tissue inflammation ( J:257980 )

• macrophage accumulation in WAT

abnormal circulating chemokine level ( J:257980 )

• plasma levels of cytokines and chemokines are increased - TNF, IL6, MCP1, MCP2, MCP3

increased circulating interleukin-6 level ( J:257980 )

increased circulating tumor necrosis factor level ( J:257980 )