Snrk^tm1.1Hxu
Targeted Allele Detail

Summary

• Symbol: Snrk^tm1.1Hxu
• Name: SNF related kinase; targeted mutation 1.1, Haiyan Xu
• MGI ID: MGI:6279960
• Synonyms: SNRK^loxp
• Gene: Snrk Location: Chr9:121946332-121998768 bp, + strand Genetic Position: Chr9, 72.89 cM
• Alliance: Snrk^tm1.1Hxu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257980
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The KOMP targeting vector was inserted at position 122156726 of Chromosome 9 upstream of exon 4 (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence, a loxP site, neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. The third loxP site is inserted downstream of exon 4 at position 122157552. Flp-mediated recombination removed the FRT-flanked lacZ/neo cassette leaving exon 4 floxed. (J:257980)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Snrk Mutation: 35 strains or lines available

References

• Original: J:257980 Li J, et al., Sucrose Nonfermenting-Related Kinase Regulates Both Adipose Inflammation and Energy Homeostasis in Mice and Humans. Diabetes. 2018 Mar;67(3):400-411
• All: 2 reference(s)