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Phenotypes Associated with This Genotype
Genotype
MGI:6279217
Allelic
Composition		 Klf2tm1Mlkn/Klf2tm1Mlkn
Krit1tm1Kwhi/Krit1tm1Kwhi
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klf2tm1Mlkn mutation (0 available); any Klf2 mutation (13 available)
Krit1tm1Kwhi mutation (0 available); any Krit1 mutation (35 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:232707 )
N
• mice exhibit 99% rescue of cerebral cavernous malformation lesion formation, with only a small amount of venule dilatation visible

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory