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Phenotypes Associated with This Genotype
Genotype
MGI:6279216
Allelic
Composition		 Klf2tm1Mlkn/Klf2+
Krit1tm1Kwhi/Krit1tm1Kwhi
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klf2tm1Mlkn mutation (0 available); any Klf2 mutation (12 available)
Krit1tm1Kwhi mutation (0 available); any Krit1 mutation (35 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal brain vasculature morphology ( J:232707 )
• tamoxifen injected mice exhibit a marked (80%) but incomplete prevention of cerebral cavernous malformation lesion formation

nervous system
abnormal brain vasculature morphology ( J:232707 )
• tamoxifen injected mice exhibit a marked (80%) but incomplete prevention of cerebral cavernous malformation lesion formation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory