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Phenotypes Associated with This Genotype
Genotype
MGI:6273518
Allelic
Composition
Krastm4Tyj/Kras+
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
Tg(Flt3-cre)#Ccb/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo mutation (6 available); any Gt(ROSA)26Sor mutation (510 available)
Krastm4Tyj mutation (6 available); any Kras mutation (35 available)
Tg(Flt3-cre)#Ccb mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die at a median age of 26 days

growth/size/body
• mice show progressive weight loss after 2 weeks of age

endocrine/exocrine glands
• mice exhibit an atrophied thymus

hematopoietic system
• mice exhibit an atrophied thymus
• mice show anemia after 2 weeks of age
• mice show thrombocytopenia after 2 weeks of age
• mice show an increase in the frequency of CD11c+dendritic cells in the bone marrow and spleen, with expansion particularly in the atrophied thymus
• mice show histiocytic infiltrate in the spleen, liver, lung and intestines and an increase in frequency of CD11b+Gr1+ cells in the blood, bone marrow, liver, and spleen
• frequency of B220+ B lymphocytes is decreased
• frequency of CD3+ T lymphocytes is decreased
• atrophied thymus shows a deficit of CD4-CD8-CD25+ committed T cell progenitors
• atrophied thymus shows a deficit of CD4+CD8+ double-positive cells
• mice show leukocytosis after 2 weeks of age
• mice show monocytosis after 2 weeks of age
• moribund mice show a reduction hematopoietic stem cells (LSK CD150+CD48-) and multipotent progenitors (LSK CD150-CD48+) in the bone marrow and spleen
• mice show hepatosplenomegaly after 2 weeks of age

immune system
• mice exhibit an atrophied thymus
• mice show an increase in the frequency of CD11c+dendritic cells in the bone marrow and spleen, with expansion particularly in the atrophied thymus
• mice show histiocytic infiltrate in the spleen, liver, lung and intestines and an increase in frequency of CD11b+Gr1+ cells in the blood, bone marrow, liver, and spleen
• frequency of B220+ B lymphocytes is decreased
• frequency of CD3+ T lymphocytes is decreased
• atrophied thymus shows a deficit of CD4-CD8-CD25+ committed T cell progenitors
• atrophied thymus shows a deficit of CD4+CD8+ double-positive cells
• mice show leukocytosis after 2 weeks of age
• mice show monocytosis after 2 weeks of age
• mice show hepatosplenomegaly after 2 weeks of age

liver/biliary system
• mice show hepatosplenomegaly after 2 weeks of age

neoplasm
• mice develop a juvenile myelomonocytic leukemia-like disease

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
juvenile myelomonocytic leukemia DOID:0050458 OMIM:607785
J:247853


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/04/2020
MGI 6.14
The Jackson Laboratory