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Phenotypes Associated with This Genotype
Genotype
MGI:6267351
Allelic
Composition		 Chaf1btm2c(EUCOMM)Hmgu/Chaf1b+
Krastm4Tyj/Kras+
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J * C57BL/6N * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chaf1btm2c(EUCOMM)Hmgu mutation (0 available); any Chaf1b mutation (33 available)
Krastm4Tyj mutation (12 available); any Kras mutation (88 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:266848 )
• in pIpC-treated mice but not as severe as when Chaf1b alleles are wild-type

hematopoietic system
hematopoietic system phenotype ( J:266848 )
N
• pIpC-treated mice exhibit normal numbers of red blood cells and platelets
increased leukocyte cell number ( J:266848 )
• in pIpC-treated mice

immune system
increased leukocyte cell number ( J:266848 )
• in pIpC-treated mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory