Phenotypes Associated with This Genotype

Genotype
MGI:6262834

• Allelic Composition: Lyn^{tm1b(EUCOMM)Hmgu}/Lyn^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Lyn^{tm1b(EUCOMM)Hmgu}/H
• Cell Lines: HEPD0704_6_B11

Data Sources

IMPC Data for Lyn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal gait ( J:211773 )

♂

IMPC - HAR

craniofacial

abnormal maxilla morphology ( J:211773 )

♀

IMPC - HAR

endocrine/exocrine glands

small thymus ( J:211773 )

♀

IMPC - HAR

growth/size/body

abnormal maxilla morphology ( J:211773 )

♀

IMPC - HAR

enlarged spleen ( J:211773 )

IMPC - HAR

increased spleen weight ( J:211773 )

IMPC - HAR

hematopoietic system

small thymus ( J:211773 )

♀

IMPC - HAR

enlarged spleen ( J:211773 )

IMPC - HAR

increased spleen weight ( J:211773 )

IMPC - HAR

increased eosinophil cell number ( J:211773 )

♂

IMPC - HAR

decreased erythrocyte cell number ( J:211773 )

IMPC - HAR

decreased hematocrit ( J:211773 )

IMPC - HAR

decreased hemoglobin content ( J:211773 )

IMPC - HAR

increased red blood cell distribution width ( J:211773 )

IMPC - HAR

increased neutrophil cell number ( J:211773 )

IMPC - HAR

thrombocytopenia ( J:211773 )

IMPC - HAR

increased mean platelet volume ( J:211773 )

♀

IMPC - HAR

increased large unstained cell number ( J:211773 )

♂

IMPC - HAR

increased monocyte cell number ( J:211773 )

IMPC - HAR

decreased leukocyte cell number ( J:211773 )

IMPC - HAR

decreased lymphocyte cell number ( J:211773 )

IMPC - HAR

homeostasis/metabolism

decreased circulating cholesterol level ( J:211773 )

IMPC - HAR

decreased circulating HDL cholesterol level ( J:211773 )

♂

IMPC - HAR

decreased circulating triglyceride level ( J:211773 )

♀

IMPC - HAR

increased circulating aspartate transaminase level ( J:211773 )

♂

IMPC - HAR

increased blood urea nitrogen level ( J:211773 )

IMPC - HAR

immune system

small thymus ( J:211773 )

♀

IMPC - HAR

enlarged spleen ( J:211773 )

IMPC - HAR

increased spleen weight ( J:211773 )

IMPC - HAR

increased eosinophil cell number ( J:211773 )

♂

IMPC - HAR

increased neutrophil cell number ( J:211773 )

IMPC - HAR

increased large unstained cell number ( J:211773 )

♂

IMPC - HAR

increased monocyte cell number ( J:211773 )

IMPC - HAR

decreased leukocyte cell number ( J:211773 )

IMPC - HAR

decreased lymphocyte cell number ( J:211773 )

IMPC - HAR

skeleton

abnormal maxilla morphology ( J:211773 )

♀

IMPC - HAR

decreased bone mineral density ( J:211773 )

♀

IMPC - HAR

vision/eye

abnormal retina morphology ( J:211773 )

♂

IMPC - HAR