Phenotypes Associated with This Genotype

Genotype
MGI:6256734

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Krt19^{tm1(cre/ERT)Ggu}/Krt19⁺; Pten^tm2Mak/Pten^tm2Mak
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:254370 )

• mice administered tamoxifen at 8 weeks of age show a median survival of 30 days after tamoxifen injection

digestive/alimentary system

abnormal colon morphology ( J:254370 )

• colonic serrated epithelial changes in tamoxifen treated mice

stomach mucosa hyperplasia ( J:254370 )

• hyperplastic changes of gastric mucosa in tamoxifen treated mice

endocrine/exocrine glands

abnormal extrahepatic bile duct morphology ( J:254370 )

• extrahepatic bile duct is rigid and dilated in tamoxifen treated mice

• papillary hyperplasia of the extrahepatic biliary tract

abnormal gallbladder morphology ( J:254370 )

• papillary hyperplasia of the gallbladder in tamoxifen treated mice

abnormal cystic duct morphology ( J:254370 )

• gallbladder and cystic duct are rigid and dilated in tamoxifen treated mice

dilated gallbladder ( J:254370 )

• in tamoxifen treated mice

increased pancreatic intraepithelial neoplasia incidence ( J:254370 )

• PanIN-like lesions and hyperplasia in the pancreatic ducts in tamoxifen treated mice

• however, no obvious tumors are seen in mice administered tamoxifen at 8 weeks of age

immune system

lung inflammation ( J:254370 )

• obstructive pneumonia in tamoxifen treated mice

liver/biliary system

abnormal extrahepatic bile duct morphology ( J:254370 )

• extrahepatic bile duct is rigid and dilated in tamoxifen treated mice

• papillary hyperplasia of the extrahepatic biliary tract

abnormal gallbladder morphology ( J:254370 )

• papillary hyperplasia of the gallbladder in tamoxifen treated mice

abnormal cystic duct morphology ( J:254370 )

• gallbladder and cystic duct are rigid and dilated in tamoxifen treated mice

dilated gallbladder ( J:254370 )

• in tamoxifen treated mice

abnormal liver morphology ( J:254370 )

• liver of tamoxifen treated mice shows pre-malignant papillary ductal lesions in periportal areas

neoplasm

increased pancreatic intraepithelial neoplasia incidence ( J:254370 )

• PanIN-like lesions and hyperplasia in the pancreatic ducts in tamoxifen treated mice

• however, no obvious tumors are seen in mice administered tamoxifen at 8 weeks of age

respiratory system

lung inflammation ( J:254370 )

• obstructive pneumonia in tamoxifen treated mice

bronchial epithelial hyperplasia ( J:254370 )

• papillary hyperplasia of bronchial epithelia in tamoxifen treated mice

respiratory failure ( J:254370 )

• respiratory failure by lung lesions in tamoxifen treated mice