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Phenotypes Associated with This Genotype
Genotype
MGI:6148038
Allelic
Composition
Adamts18tm1.1Wzha/Adamts18tm1.1Wzha
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts18tm1.1Wzha mutation (0 available); any Adamts18 mutation (66 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• increased intestinal inflammation and mucosal dysplasia in mice treated with azoxymethane and 3 rounds of dextran sodium sulfate compared to similarly treated controls
• increased incidence rate and tumor numbers following treatment with azoxymethane and 3 rounds of dextran sodium sulfate compared to similarly treated controls

digestive/alimentary system
• in mice treated with azoxymethane and 3 rounds of dextran sodium sulfate compared to similarly treated controls
• in mice treated with azoxymethane and 3 rounds of dextran sodium sulfate compared to similarly treated controls
• in a DSS-induced model mice show severe bloody stools, significant weight loss, and shorter colon lengths

growth/size/body
• seen in a substantial fraction of mice

respiratory system
• seen in a substantial fraction of mice

vision/eye
• seen in a substantial fraction of mice

immune system
• in a DSS-induced model mice show severe bloody stools, significant weight loss, and shorter colon lengths
• increased intestinal inflammation in mice treated with azoxymethane and 3 rounds of dextran sodium sulfate compared to similarly treated controls

endocrine/exocrine glands
• in mice treated with azoxymethane and 3 rounds of dextran sodium sulfate compared to similarly treated controls

neoplasm
• increased incidence rate and tumor numbers following treatment with azoxymethane and 3 rounds of dextran sodium sulfate compared to similarly treated controls

cellular
• in mice treated with azoxymethane and 3 rounds of dextran sodium sulfate compared to similarly treated controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/28/2026
MGI 6.24
The Jackson Laboratory