Phenotypes Associated with This Genotype

Genotype
MGI:6116483

• Allelic Composition: Cxcr4^tm2Yzo/Cxcr4^tm2Yzo; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased subcutaneous adipose tissue amount ( J:217569 )

• 1.8-fold in mice fed a high-fat diet

increased total body fat amount ( J:217569 )

• 2-fold increase in mice fed a high-fat diet

increased brown adipose tissue mass ( J:217569 )

• 2-fold in mice fed a high-fat diet

increased brown fat cell size ( J:217569 )

• in mice fed a high-fat diet

increased white fat cell size ( J:217569 )

• in mice fed a high-fat diet

increased gonadal fat pad weight ( J:217569 )

• 1.6-fold in visceral (mesenteric, retroperitoneal, and gonadal) white adipose tissue mice fed a high-fat diet

increased mesenteric fat pad weight ( J:217569 )

• 1.6-fold in visceral (mesenteric, retroperitoneal, and gonadal) white adipose tissue mice fed a high-fat diet

increased retroperitoneal fat pad weight ( J:217569 )

• 1.6-fold in visceral (mesenteric, retroperitoneal, and gonadal) white adipose tissue mice fed a high-fat diet

increased white adipose tissue mass ( J:217569 )

• in mice fed a high-fat diet

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:217569 )

N • mice fed a high-fat diet exhibit normal glucose sensitivity as similarly treated wild-type mice

increased susceptibility to diet-induced obesity ( J:217569 )

• in mice fed a high-fat diet despite normal food intake

• however, mice fed standard chow exhibit normal weight

impaired adaptive thermogenesis ( J:217569 )

• cold-exposed mice fed a high-fat diet exhibit lower body temperatures compared with wild-type mice

• however, body temperature when housed at 25 degrees Celsius is normal

decreased oxygen consumption ( J:217569 )

• in mice fed a high-fat diet during the light and dark phase

• however, oxygen consumption normalized to lean body mass is normal

immune system

decreased B cell number ( J:217569 )

• in the white adipose tissue of mice fed a high-fat diet

decreased CD4-positive, alpha-beta T cell number ( J:217569 )

• 2.4-fold decrease in the white adipose tissue of mice fed a high-fat diet

increased CD8-positive, alpha-beta T cell number ( J:217569 )

• 2.6-fold increase in the white adipose tissue of mice fed a high-fat diet

abnormal macrophage cell number ( J:217569 )

• increased F4/80+CD11b+CD206-CD11c+ M1 adipose tissue macrophages in the white adipose tissue of mice fed a high-fat diet

• 2.3-fold decreased F4/80+CD11b+CD206+CD11c- M2 adipose tissue macrophages in the white adipose tissue of mice fed a high-fat diet

growth/size/body

growth/size/body region phenotype ( J:217569 )

N • mice fed standard chow or a high-fat diet exhibit normal lean mass

increased susceptibility to diet-induced obesity ( J:217569 )

• in mice fed a high-fat diet despite normal food intake

• however, mice fed standard chow exhibit normal weight

hematopoietic system

decreased B cell number ( J:217569 )

• in the white adipose tissue of mice fed a high-fat diet

decreased CD4-positive, alpha-beta T cell number ( J:217569 )

• 2.4-fold decrease in the white adipose tissue of mice fed a high-fat diet

increased CD8-positive, alpha-beta T cell number ( J:217569 )

• 2.6-fold increase in the white adipose tissue of mice fed a high-fat diet

abnormal macrophage cell number ( J:217569 )

• increased F4/80+CD11b+CD206-CD11c+ M1 adipose tissue macrophages in the white adipose tissue of mice fed a high-fat diet

• 2.3-fold decreased F4/80+CD11b+CD206+CD11c- M2 adipose tissue macrophages in the white adipose tissue of mice fed a high-fat diet

integument

increased subcutaneous adipose tissue amount ( J:217569 )

• 1.8-fold in mice fed a high-fat diet