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Phenotypes Associated with This Genotype
Genotype
MGI:5927438
Allelic
Composition		 Tg(Acta2-cre/ERT2)#Pcn/0
Tgfbr2tm1Karl/Tgfbr2tm1Karl
Tg(H2-K-Fosl2,-EGFP)13Wag/0
Genetic
Background		 B6.Cg-Tgfbr2tm1Karl Tg(Acta2-cre/ERT2)#Pcn Tg(H2-K-Fosl2,-EGFP)13Wag
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Acta2-cre/ERT2)#Pcn mutation (0 available)
Tgfbr2tm1Karl mutation (1 available); any Tgfbr2 mutation (40 available)
Tg(H2-K-Fosl2,-EGFP)13Wag mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
lung inflammation ( J:238723 )
• mice treated with tamoxifen show similar lung inflammation as single Tg(H2-K-Fosl2,EGFP)13Wag mice
pulmonary fibrosis ( J:238723 )
• mice treated with tamoxifen show similar pulmonary fibrosis as single Tg(H2-K-Fosl2,EGFP)13Wag mice

immune system
lung inflammation ( J:238723 )
• mice treated with tamoxifen show similar lung inflammation as single Tg(H2-K-Fosl2,EGFP)13Wag mice

cardiovascular system
cardiovascular system phenotype ( J:238723 )
N
• mice treated with tamoxifen show diminished expansion of the smooth muscle cell area in pulmonary arteries and reduced proliferation of pulmonary artery smooth muscle cells that is seen in single Tg(H2-K-Fosl2,EGFP)13Wag mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory