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Phenotypes Associated with This Genotype
Genotype
MGI:5910547
Allelic
Composition
Ergtm1.1Iwamo/Ergtm1.1Iwamo
Tg(Gdf5-cre-ALPP)1Kng/?
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ergtm1.1Iwamo mutation (1 available); any Erg mutation (1 available)
Tg(Gdf5-cre-ALPP)1Kng mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• 8 week old mice are more susceptible to surgically induced osteoarthritis in knees than controls
• 4 weeks post-surgery articular cartilage is eroded and the region develops ectopic chondrocyte hypertrophy and is lacking Safranin O-staining proteoglycans and lubricin
• knee articular cartilage is thin, eroded and almost absent in joints of 6-7 month old mice
• tibial plateau exhibits arthritic changes based on osteoarthritis assessment criteria
• knee joint surface of the femur exhibits arthritic changes based on osteoarthritis assessment criteria
• knee articular cartilage is thin, eroded and almost absent in joints of 6-7 month old mice

immune system
• 8 week old mice are more susceptible to surgically induced osteoarthritis in knees than controls
• 4 weeks post-surgery articular cartilage is eroded and the region develops ectopic chondrocyte hypertrophy and is lacking Safranin O-staining proteoglycans and lubricin
• knee articular cartilage is thin, eroded and almost absent in joints of 6-7 month old mice
• tibial plateau exhibits arthritic changes based on osteoarthritis assessment criteria
• knee joint surface of the femur exhibits arthritic changes based on osteoarthritis assessment criteria

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
osteoarthritis DOID:8398 J:243715


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory