Phenotypes Associated with This Genotype

Genotype
MGI:5907168

• Allelic Composition: Anp32b^tm1Mak/Anp32b^tm1Mak
• Genetic Background: C.129P2(B6)-Anp32b^tm1Mak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:227403 )

• mice die prematurely but on no consistent cause with mice exhibiting a variety of illnesses (hydrocephalus, pulmonary adenoma, lymphoid aggregates on lungs, hyperplastic salivary gland, hamartoma of cardiomyocytes in the lung, segmental aplasia of the uterine horn, cardiomegaly, and dilated pancreatic ducts)

postnatal lethality, incomplete penetrance ( J:227403 )

• Background Sensitivity: fewer than mice on a congenic BALB/c background survive than expected although the decrease is not as severe as on a congenic C57BL/6J or FVB/N background due to the presence of modifier gene(s)

reproductive system

reproductive system phenotype ( J:227403 )

N • surviving mice are fertile

homeostasis/metabolism

decreased circulating bilirubin level ( J:227403 )

decreased circulating cholesterol level ( J:227403 )

decreased circulating HDL cholesterol level ( J:227403 )

decreased circulating total protein level ( J:227403 )

increased incidence of tumors by chemical induction ( J:227403 )

• increased DMBA-induced cutaneous squamous cell carcinomas

• however, DMBA induced mammary gland, ovarian and lymphoid tumors are the same as in wild-type mice

neoplasm

increased incidence of tumors by chemical induction ( J:227403 )

• increased DMBA-induced cutaneous squamous cell carcinomas

• however, DMBA induced mammary gland, ovarian and lymphoid tumors are the same as in wild-type mice

growth/size/body

decreased body weight ( J:227403 )