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Phenotypes Associated with This Genotype
Genotype
MGI:5907132
Allelic
Composition		 Mdm4tm2Glo/Mdm4tm2.1Glo
Tg(Myh6-cre)2182Mds/0
Trp53tm1Tyj/Trp53+
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4tm2.1Glo mutation (0 available); any Mdm4 mutation (190 available)
Mdm4tm2Glo mutation (1 available); any Mdm4 mutation (190 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (237 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
extended life span ( J:137114 )
• mice show an extended median survival of 274 days compared to compound heterozygous Mdm4tm2Glo/Mdm4tm2.1Glo conditional mutants

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory