Phenotypes Associated with This Genotype

Genotype
MGI:5905988

• Allelic Composition: Tg(KRT5-rtTA)#Glk/0; Tg(tetO-cre)1Jaw/0; Wnt10a^tm1Smr/Wnt10a^tm1Smr
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

enlarged sebaceous gland ( J:242196 )

• when treated with doxycycline at P25

abnormal sweat gland morphology ( J:242196 )

• fail to extend when treated with doxycycline in early postnatal life

• regression of sweat glands when treated with doxycycline at P20

abnormal sebaceous lipid secretion ( J:242196 )

• elevated lipid production when treated with doxycycline at P25

hypohidrosis ( J:242196 )

• when treated with doxycycline at P20

small hair follicles ( J:242196 )

• minitaturized when treated with doxycycline at P25

abnormal hair cycle anagen phase ( J:242196 )

• delayed initiation of anagen until P29, when treated with doxycycline at P18

accelerated hair follicle regression ( J:242196 )

• premature when treated with doxycycline at P9

• however, hair follicle regression isnt observed when treated with doxycycline at P25

abnormal hair follicle physiology ( J:242196 )

• slightly reduced proliferation when treated with doxycycline at P25

craniofacial

abnormal tongue morphology ( J:242196 )

• flattened surface when treated with doxycycline in early postnatal life

abnormal filiform papillae morphology ( J:242196 )

• progressive from P7 when treated with doxycycline in early postnatal life

abnormal fungiform papillae morphology ( J:242196 )

• progressive from P7 when treated with doxycycline in early postnatal life

abnormal gustatory papilla taste bud morphology ( J:242196 )

• miniaturized when treated with doxycycline in early postnatal life

• decreased taste bud in fungiform and circumvallate papillae when treated with doxycycline in early postnatal life

cellular

decreased cell proliferation ( J:242196 )

• decreased basal cell proliferation in the filiform papillae and plantar epithelium, fungiform and circumvallate taste buds and sweat buds when treated with doxycycline at in either the early postnatal period, or in adult life

taste/olfaction

abnormal gustatory papilla taste bud morphology ( J:242196 )

• miniaturized when treated with doxycycline in early postnatal life

• decreased taste bud in fungiform and circumvallate papillae when treated with doxycycline in early postnatal life

digestive/alimentary system

abnormal tongue morphology ( J:242196 )

• flattened surface when treated with doxycycline in early postnatal life

abnormal filiform papillae morphology ( J:242196 )

• progressive from P7 when treated with doxycycline in early postnatal life

abnormal fungiform papillae morphology ( J:242196 )

• progressive from P7 when treated with doxycycline in early postnatal life

abnormal gustatory papilla taste bud morphology ( J:242196 )

• miniaturized when treated with doxycycline in early postnatal life

• decreased taste bud in fungiform and circumvallate papillae when treated with doxycycline in early postnatal life

endocrine/exocrine glands

enlarged sebaceous gland ( J:242196 )

• when treated with doxycycline at P25

abnormal sweat gland morphology ( J:242196 )

• fail to extend when treated with doxycycline in early postnatal life

• regression of sweat glands when treated with doxycycline at P20

abnormal sebaceous lipid secretion ( J:242196 )

• elevated lipid production when treated with doxycycline at P25

hypohidrosis ( J:242196 )

• when treated with doxycycline at P20

growth/size/body

abnormal tongue morphology ( J:242196 )

• flattened surface when treated with doxycycline in early postnatal life

abnormal filiform papillae morphology ( J:242196 )

• progressive from P7 when treated with doxycycline in early postnatal life

abnormal fungiform papillae morphology ( J:242196 )

• progressive from P7 when treated with doxycycline in early postnatal life

abnormal gustatory papilla taste bud morphology ( J:242196 )

• miniaturized when treated with doxycycline in early postnatal life

• decreased taste bud in fungiform and circumvallate papillae when treated with doxycycline in early postnatal life