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Phenotypes Associated with This Genotype
Genotype
MGI:5902136
Allelic
Composition		 Braftm1Mmcm/Braf+
Ptentm2.1Ppp/Pten+
Tg(Tyr-cre/ERT2)13Bos/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1Mmcm mutation (4 available); any Braf mutation (61 available)
Ptentm2.1Ppp mutation (0 available); any Pten mutation (87 available)
Tg(Tyr-cre/ERT2)13Bos mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
increased cutaneous melanoma incidence ( J:151023 )
• 4-HT treated mice eventually develop focal malignant melanomas

neoplasm
increased cutaneous melanoma incidence ( J:151023 )
• 4-HT treated mice eventually develop focal malignant melanomas

pigmentation
abnormal melanocyte morphology ( J:151023 )
• 4-hydroxytamoxifen (4-HT) treated mice initially develop benign melanocytic lesions but they eventually develop focal malignant melanomas

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory