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Phenotypes Associated with This Genotype
Genotype
MGI:5898013
Allelic
Composition		 Ino80tm1.1Schg/Ino80+
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ino80tm1.1Schg mutation (0 available); any Ino80 mutation (437 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (238 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:221224 )
• 7 of 20 mice develop thymic lymphomas

neoplasm
increased T cell derived lymphoma incidence ( J:221224 )
• 7 of 20 mice develop thymic lymphomas
decreased lymphoma incidence ( J:221224 )
• lower incidence of lymphomas compared to Trp53tm1Tyj null mice
increased sarcoma incidence ( J:221224 )
• 10 of 20 mice develop poorly differentiated and highly invasive soft tissue sarcomas
• while double mutants exhibit an altered spectrum of tumors compared to single Trp53tm1Tyj, tumor incidence and latency are similar to these mice

hematopoietic system
increased T cell derived lymphoma incidence ( J:221224 )
• 7 of 20 mice develop thymic lymphomas

immune system
increased T cell derived lymphoma incidence ( J:221224 )
• 7 of 20 mice develop thymic lymphomas

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/31/2026
MGI 6.24 		The Jackson Laboratory