Phenotypes Associated with This Genotype

Genotype
MGI:5897857

• Allelic Composition: Braf^tm1Mmcm/Braf⁺; Trp53^tm3.1Tyj/Trp53⁺; Tg(TPO-cre/ERT2)1139Tyj/0
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:208854 )

• tamoxifen treated mice exhibit shortened survival

endocrine/exocrine glands

increased thyroid carcinoma incidence ( J:208854 )

• tamoxifen treated mice develop large papillary thyroid carcinoma that exhibit features associated with aggressive behavior including solid growth, tall cell morphology, focal necrosis, and hobnail features

• about 50% of mice with papillary thyroid carcinoma acquire poorly differentiated thyroid carcinoma or undifferentiated anaplastic thyroid carcinoma

neoplasm

increased thyroid carcinoma incidence ( J:208854 )

• tamoxifen treated mice develop large papillary thyroid carcinoma that exhibit features associated with aggressive behavior including solid growth, tall cell morphology, focal necrosis, and hobnail features

• about 50% of mice with papillary thyroid carcinoma acquire poorly differentiated thyroid carcinoma or undifferentiated anaplastic thyroid carcinoma