Phenotypes Associated with This Genotype

Genotype
MGI:5897668

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Pten^tm2.1Ppp/Pten^tm2.1Ppp; Tg(TPO-cre)1Shk/0
• Genetic Background: 129.Cg-Kras^tm4Tyj Tg(Tpo-cre)1Shk Pten^tm2.1Ppp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:147732 )

• 50% of mice die within 7 weeks from birth and none survive over 4 months of age

• treatment with LY294002, an inhibitor of PI3K, twice a week starting at 3 weeks of age prolongs survival of mice

endocrine/exocrine glands

enlarged thyroid gland ( J:147732 )

• mice develop thyroids 200- to 500-fold larger than controls

increased thyroid carcinoma incidence ( J:147732 )

• mice rapidly develop thyroid follicular carcinomas

• 30-90% of the thyroid glands are replaced by microfollicular to solid areas, indicating thyroid follicular cancer, including capsular, muscle, and vascular invasion

homeostasis/metabolism

increased thyroxine level ( J:147732 )

decreased circulating thyroid-stimulating hormone level ( J:147732 )

neoplasm

increased thyroid carcinoma incidence ( J:147732 )

• mice rapidly develop thyroid follicular carcinomas

• 30-90% of the thyroid glands are replaced by microfollicular to solid areas, indicating thyroid follicular cancer, including capsular, muscle, and vascular invasion

increased metastatic potential ( J:147732 )

• all mice surviving at least 12 weeks develop thyroglobulin-positive lung metastases