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Phenotypes Associated with This Genotype
Genotype
MGI:5882503
Allelic
Composition
Cpeb2tm1.1Yshu/Cpeb2tm1.1Yshu
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: C57BL/6 * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpeb2tm1.1Yshu mutation (0 available); any Cpeb2 mutation (24 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• whole-body plethysmography revealed severe respiratory defects, similar to those observed in Cpeb2tm1.2Yshu homozygotes
• however, tidal volume is normal at P1
• pups exhibit aberrant respiration patterns at P1
• significantly reduced respiratory frequency at P1
• significantly increased apneic episodes at P1

nervous system
• pulmonary acetylcholine level is significantly increased at P1

homeostasis/metabolism
• pulmonary acetylcholine level is significantly increased at P1
• choline acetyltransferase (ChAT) expression is increased by ~20% in the dorsal motor nucleus of vagus (DMNV)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory