Phenotypes Associated with This Genotype

Genotype
MGI:5882503

• Allelic Composition: Cpeb2^tm1.1Yshu/Cpeb2^tm1.1Yshu; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal whole-body plethysmography ( J:237513 )

• whole-body plethysmography revealed severe respiratory defects, similar to those observed in Cpeb2^tm1.2Yshu homozygotes

• however, tidal volume is normal at P1

abnormal breathing pattern ( J:237513 )

• pups exhibit aberrant respiration patterns at P1

decreased pulmonary respiratory rate ( J:237513 )

• significantly reduced respiratory frequency at P1

apnea ( J:237513 )

• significantly increased apneic episodes at P1

respiratory failure ( J:237513 )

homeostasis/metabolism

increased acetylcholine level ( J:237513 )

• pulmonary acetylcholine level is significantly increased at P1

increased brain choline acetyltransferase activity ( J:237513 )

• choline acetyltransferase (ChAT) expression is increased by ~20% in the dorsal motor nucleus of vagus (DMNV)