Phenotypes Associated with This Genotype

Genotype
MGI:5817471

• Allelic Composition: Rai1^tm2.1Luo/Rai1^tm2.1Luo; Tg(Nes-cre)1Kln/?
• Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:237687 )

♂N • males perform similar to controls in assays for gait, velocity, vertical activity, anxiety, sociability and cognition

♂N • males have normal hearing and pain responses

abnormal associative learning ( J:237687 )

♂ • decreased freezing behavior after repeated tone-shock pairings during training

impaired contextual conditioning behavior ( J:237687 )

♂ • decreased freezing behavior in contextual recall in trace fear-conditioning task

impaired cued conditioning behavior ( J:237687 )

♂ • decreased freezing behavior in cued recall

abnormal spatial working memory ( J:237687 )

♂ • reduced tendency to explore new arm in Y maze

limb grasping ( J:237687 )

• hindlimb clasping

impaired coordination ( J:237687 )

♂ • in pole test males slip from pole or climb down in a slow and uncoordinated fashion

♂ • decreased latency to fall in wire hang test

growth/size/body

obese ( J:237687 )

♀ • female mice become overweight beginning at 5 weeks of age

♀ • at 20 weeks female mice are 101% heavier than controls

decreased body size ( J:237687 )

• mice are smaller than littermates prior to weaning

mortality/aging

premature death ( J:237687 )

• more than 80% of mice die before 25 weeks of age

skeleton

kyphosis ( J:237687 )

• kyphosis in 10% of mice that die before 10 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Smith-Magenis syndrome		DOID:0060768	OMIM:182290	J:237687