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Phenotypes Associated with This Genotype
Genotype
MGI:5811096
Allelic
Composition		 Rag2tm1Fwa/Rag2tm1Fwa
Tg(Cd4-NPM/ALK)N1Ingh/0
Tg(TcraTcrb)1100Mjb/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (115 available)
Tg(Cd4-NPM/ALK)N1Ingh mutation (0 available)
Tg(TcraTcrb)1100Mjb mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased gastrointestinal stromal tumor incidence ( J:235890 )
• mice do not develop lymphoid tumors, but present after a long latency with gastrointestinal stromal tumors
increased hepatocellular carcinoma incidence ( J:235890 )
• mice present after a long latency with hepatocellular carcinomas and sarcomas
increased sarcoma incidence ( J:235890 )
• mice present after a long latency with hepatocellular carcinomas and sarcomas

digestive/alimentary system
increased gastrointestinal stromal tumor incidence ( J:235890 )
• mice do not develop lymphoid tumors, but present after a long latency with gastrointestinal stromal tumors

liver/biliary system
increased hepatocellular carcinoma incidence ( J:235890 )
• mice present after a long latency with hepatocellular carcinomas and sarcomas

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory