Phenotypes Associated with This Genotype

Genotype
MGI:5806734

• Allelic Composition: Atg3^tm1.1Ywh/Atg3^tm1.1Ywh; Fnip1^m1Btlr/Fnip1^m1Btlr; Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

absent B cells ( J:234285 )

• in the spleen and bone marrow B cell subsets of tamoxifen-treated mice

cellular

abnormal autophagy ( J:234285 )

• tamoxifen-treated B cell precursors fail to exhibit an increase in bafilomycin-induced autophagy unlike in control cells

hematopoietic system

absent B cells ( J:234285 )

• in the spleen and bone marrow B cell subsets of tamoxifen-treated mice

homeostasis/metabolism

abnormal autophagy ( J:234285 )

• tamoxifen-treated B cell precursors fail to exhibit an increase in bafilomycin-induced autophagy unlike in control cells