Phenotypes Associated with This Genotype

Genotype
MGI:5795689

• Allelic Composition: Camk2a^tm1.1Yelg/Camk2a^tm1.1Yelg; Emx1^{tm1.1(cre)Ito}/0
• Genetic Background: B6J.Cg-Camk2a^tm1.1Yelg Emx1^{tm1.1(cre)Ito}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired contextual conditioning behavior ( J:216169 )

• mice show severe contextual fear learning deficits relative to control littermates, as revealed by a marked reduction in elicited freezing behavior

impaired spatial learning ( J:216169 )

• in the hidden version of the Morris water maze, mice search equally in all four quadrants with no clear preference for the target quadrant during the probe trial, and show a significant reduction in their latency time to reach the hidden platform at day 3, but not at the initial or final (day 5) training days relative to control littermates

• however, no significant differences in thigmotaxis, swim speed, or path length are observed