Analysis Tools
renal/urinary system
|
• apoptosis is frequently seen in shedding cells in both the Bowman space and in the lumen of the tubules, occurring more frequently at P50
|
|
• the tubular epithelium and parietal cells of the renal corpuscles show increased cellular proliferation in the phase of cyst growth
|
|
• mice develop progressively massive proteinuria, consisting mainly of albuminuria that is already higher at P30
|
albuminuria
(
J:229188
)
|
• seen by P30
|
|
• at P30, urinary osmolality is lower, with no changes in urinary ouput or in collecting duct distribution
|
|
• kidneys at P50 have a rough surface
|
|
• at P50, primary cilia are rare in the epithelium of dilating tubules and absent in enlarged cysts with flattened epithelium, indicating a progressive loss of primary cilia with cyst enlargement
|
|
• at P50, mice exhibit cortical cysts
• cysts originate from the renal corpuscles of the cortex and are absent in the outer and inner medulla
|
|
• the density of collecting ducts is lower at P50
|
|
• the tubular epithelium and parietal cells of the renal corpuscles show increased cellular proliferation in the phase of cyst growth, before flattening of the cystic epithelium
|
|
• dilatation of the parietal cells of the Bowman capsule
|
|
• glomeruli progressively shrink
• mice develop glomerulocystic disease
|
|
• epithelium lining the cyst flattens and interstitial fibrosis develops
|
|
• mice present lower kidney weight at P50, with the ratio of kidney weight/body weight being lower at P50 but not P30
|
|
• tubular dilatations are mainly cortical and develop progressively at P50
|
pale kidney
(
J:229188
)
|
• kidneys at P50 have a paler color
|
isosthenuria
(
J:229188
)
|
• progressive impairment of urinary concentrating ability
|
cellular
|
• at P50, primary cilia are rare in the epithelium of dilating tubules and absent in enlarged cysts with flattened epithelium, indicating a progressive loss of primary cilia with cyst enlargement
|
|
• apoptosis is frequently seen in shedding cells in both the Bowman space and in the lumen of the tubules, occurring more frequently at P50
|
|
• the tubular epithelium and parietal cells of the renal corpuscles show increased cellular proliferation in the phase of cyst growth
|
growth/size/body
|
• mice present lower body weight at P30
|
|
• at P50, mice exhibit cortical cysts
• cysts originate from the renal corpuscles of the cortex and are absent in the outer and inner medulla
|
homeostasis/metabolism
|
• mice develop progressively massive proteinuria, consisting mainly of albuminuria that is already higher at P30
|
albuminuria
(
J:229188
)
|
• seen by P30
|
|
• at P30, urinary osmolality is lower, with no changes in urinary ouput or in collecting duct distribution
|
behavior/neurological
|
• increase in water intake at P30 and P50
|
