Phenotypes Associated with This Genotype

Genotype
MGI:5789378

• Allelic Composition: Alk^tm2.1Ics/Alk⁺
• Genetic Background: B6N.129S2(Cg)-Alk^tm2.1Ics

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:226655 )

♂ • the movement response to hypercapnia is disrupted

♂ • however, mice do not show differences in the Y-maze or the tail suspension tests

decreased food intake ( J:226655 )

♂ • 48% of newborn mutants have a full stomach compared to 61% of wild-type mice, indicating some reduction in milk intake

increased anxiety-related response ( J:226655 )

♂ • during the dark/light test, mice spend less time in the light side, wait longer before going for the first time in the light side and do less light/dark transitions

increased grip strength ( J:226655 )

♂ • mice show increased muscle strength when allowed to grip with all paws

decreased vertical activity ( J:226655 )

♂ • mice exhibit less rears during the dark phase

decreased locomotor activity ( J:226655 )

♂ • mice exhibit less locomotor activity during the dark phase

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:226655 )

♂ • slightly higher levels

increased circulating chloride level ( J:226655 )

♂ • slightly higher levels

vision/eye

abnormal eye morphology ( J:226655 )

♂ • 7 of 11 mice exhibit minor abnormalities of the visual system, showing a small zone of higher reflectance under one of the main blood vessels and/or a small white spot under a vein