Phenotypes Associated with This Genotype

Genotype
MGI:5787932

• Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu; Tg(Mx1-cre)1Cgn/0
• Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Pten^tm1Hwu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:232645 )

• median survival of poly(I:C) injected mice at P8 is 35 days

hematopoietic system

enlarged spleen ( J:232645 )

• mice injected with poly(I:C) at P8 exhibit increased spleen size

increased spleen weight ( J:232645 )

• mice injected with poly(I:C) at P8 exhibit increased spleen weight

anemia ( J:232645 )

• mice injected with poly(I:C) at P8 exhibit anemia 2-3 weeks post induction

increased granulocyte number ( J:232645 )

• mice injected with poly(I:C) at P8 show an elevation in granulocytes 2-3 weeks post induction

thrombocytosis ( J:232645 )

• mice injected with poly(I:C) at P8 exhibit increased platelets 2-3 weeks post induction, although the level of platelet increase in smaller than in mice also heterozygous for Nf1^tm1Fcr

decreased lymphocyte cell number ( J:232645 )

• mice injected with poly(I:C) at P8 show a reduction in lymphocytes 2-3 weeks post induction

decreased B cell number ( J:232645 )

• mice injected with poly(I:C) at P8 show decreased B-cell (CD19+) populations in PB and spleen at 2-3 weeks post induction

decreased T cell number ( J:232645 )

• mice injected with poly(I:C) at P8 show decreased T-cell (CD3e+) populations in PB and spleen at 2-3 weeks post induction

increased macrophage cell number ( J:232645 )

• mice injected with poly(I:C) at P8 show substantial macrophage infiltration in the spleens, livers, and lungs at 2-3 weeks post induction

increased monocyte cell number ( J:232645 )

• mice injected with poly(I:C) at P8 show an elevation in monocytes in the spleens, livers, and lungs at 2-3 weeks post induction

immune system

enlarged spleen ( J:232645 )

• mice injected with poly(I:C) at P8 exhibit increased spleen size

increased spleen weight ( J:232645 )

• mice injected with poly(I:C) at P8 exhibit increased spleen weight

increased granulocyte number ( J:232645 )

• mice injected with poly(I:C) at P8 show an elevation in granulocytes 2-3 weeks post induction

decreased lymphocyte cell number ( J:232645 )

• mice injected with poly(I:C) at P8 show a reduction in lymphocytes 2-3 weeks post induction

decreased B cell number ( J:232645 )

• mice injected with poly(I:C) at P8 show decreased B-cell (CD19+) populations in PB and spleen at 2-3 weeks post induction

decreased T cell number ( J:232645 )

• mice injected with poly(I:C) at P8 show decreased T-cell (CD3e+) populations in PB and spleen at 2-3 weeks post induction

increased macrophage cell number ( J:232645 )

• mice injected with poly(I:C) at P8 show substantial macrophage infiltration in the spleens, livers, and lungs at 2-3 weeks post induction

increased monocyte cell number ( J:232645 )

• mice injected with poly(I:C) at P8 show an elevation in monocytes in the spleens, livers, and lungs at 2-3 weeks post induction

liver/biliary system

abnormal liver size ( J:232645 )

• mice injected with poly(I:C) at P8 exhibit increased liver size

increased liver weight ( J:232645 )

• mice injected with poly(I:C) at P8 exhibit increased liver weight

neoplasm

increased tumor incidence ( J:232645 )

• mice injected with poly(I:C) at 6 weeks of age develop a transient myeloproliferative neoplasm after 3 weeks post induction and 5/7 transform to T-ALL

increased T cell acute lymphoblastic leukemia incidence ( J:232645 )

• mice injected with poly(I:C) at 6 weeks of age develop a transient myeloproliferative neoplasm after 3 weeks post induction and 5/7 transform to T-ALL

growth/size/body

increased liver weight ( J:232645 )

• mice injected with poly(I:C) at P8 exhibit increased liver weight

enlarged spleen ( J:232645 )

• mice injected with poly(I:C) at P8 exhibit increased spleen size

increased spleen weight ( J:232645 )

• mice injected with poly(I:C) at P8 exhibit increased spleen weight