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Phenotypes Associated with This Genotype
Genotype
MGI:5787926
Allelic
Composition		 Alpltm1Jlm/Alpltm1Jlm
Spp1tm1Rit/Spp1tm1Rit
Genetic
Background		 involves: 129S1/SvImJ * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alpltm1Jlm mutation (0 available); any Alpl mutation (350 available)
Spp1tm1Rit mutation (6 available); any Spp1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal tooth root development ( J:233260 )
• root dentin defects that are indistinguishable from single Alpltm1Jlm homozygotes
abnormal dentin morphology ( J:233260 )
• root dentin defects that are indistinguishable from single Alpltm1Jlm homozygotes

growth/size/body
abnormal tooth root development ( J:233260 )
• root dentin defects that are indistinguishable from single Alpltm1Jlm homozygotes
abnormal dentin morphology ( J:233260 )
• root dentin defects that are indistinguishable from single Alpltm1Jlm homozygotes

skeleton
abnormal tooth root development ( J:233260 )
• root dentin defects that are indistinguishable from single Alpltm1Jlm homozygotes
abnormal dentin morphology ( J:233260 )
• root dentin defects that are indistinguishable from single Alpltm1Jlm homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory