Phenotypes Associated with This Genotype

Genotype
MGI:5776355

• Allelic Composition: Shank3^tm5.1Gfng/Shank3^tm5.1Gfng; Tg(CAG-cre/Esr1*)1Lbe/0
• Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased exploration in new environment ( J:229668 )

• prior to tamoxifen administration, mice exhibit decreased total distance travelled in open field test as compared to controls

• following tamoxifen administration, phenotype is unchanged

increased anxiety-related response ( J:229668 )

• prior to tamoxifen administration, mice spend less time in open arm during elevated zero maze test as compared to controls

• following tamoxifen administration at P20-21, mice exhibit reduced anxiety in the maze test

• tamoxifen administration in adult mice results in an unchanged phenotype

increased grooming behavior ( J:229668 )

• prior to tamoxifen administration, mice exhibit repetitive grooming

• following tamoxifen administration, grooming is similar to control

impaired coordination ( J:229668 )

• prior to tamoxifen administration, mice exhibit decreased latency to fall in rotarod test as compared to controls

• following tamoxifen administration at P20-21, mice perform significantly better on rotarod

• tamoxifen administration in adult mice results in an unchanged phenotype

decreased vertical activity ( J:229668 )

• prior to tamoxifen administration, mice exhibit reduced rearing time and frequency as compared to controls

• following tamoxifen administration, phenotype is unchanged

abnormal social investigation ( J:229668 )

• prior to tamoxifen administration, mice exhibit no preference for a stranger mouse or novel object in a test of voluntary social interaction

• following tamoxifen administration, mice exhibit a preference for a stranger mouse over a novel object in a test of voluntary social interaction

growth/size/body

decreased body weight ( J:229668 )

• as compared to wild-type mice (no tamoxifen administered)

nervous system

abnormal medium spiny neuron morphology ( J:229668 )

• prior to tamoxifen administration, mice exhibit a reduction of spine density in medium spiny neurons as compared to controls

• following tamoxifen administration, spine density is increased to a greater density than controls

abnormal dendritic spine morphology ( J:229668 )

• prior to tamoxifen administration, mice exhibit a reduction of spine density in medium spiny neurons

• following tamoxifen administration, spine density is increased to a greater density than controls

decreased excitatory postsynaptic current amplitude ( J:229668 )

• prior to tamoxifen administration, mice exhibit a reduced field population spikes in the dorsal striatum as compared to controls

• following tamoxifen administration, mice exhibit field responses similar to control

abnormal miniature excitatory postsynaptic currents ( J:229668 )

• prior to tamoxifen administration, mice exhibit a reduced mEPSC frequency as compared to controls

• following tamoxifen administration, mice exhibit mEPSC frequencies similar to control