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Phenotypes Associated with This Genotype
Genotype
MGI:5775189
Allelic
Composition
Engtm2.1Hma/Engtm2.1Hma
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Engtm2.1Hma mutation (1 available); any Eng mutation (14 available)
Gt(ROSA)26Sortm1(cre/ERT)Nat mutation (1 available); any Gt(ROSA)26Sor mutation (492 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice display signs of illness in 3-4 days after the first tamoxifen injection which includes slow movement

cardiovascular system
• adults injected with tamoxifen for 3 days develop arteriovenous malformations in AAV-VEGF-induced brain angiogenic foci 8 weeks after induction, with lesions consisting of enlarged vessels (J:212952)
• tamoxifen treated adults develop arteriovenous malformations around the ear-tag wound (J:212952)
• areas of wounds in mid-dorsum and ear of tamoxifen-injected mice show the presence of arteriovenous (AV) shunts (J:227170)
• macrophages and microhemorrhage are seen around dysplastic vessels of AAV-VEGF injected, tamoxifen treated mice in the brain
• tamoxifen treated adults develop arteriovenous malformations around the ear-tag wound (J:212952)
• areas of wounds in mid-dorsum and ear of tamoxifen-injected mice show dilated and torturous vessels and the presence of arteriovenous (AV) shunts (J:227170)
• however, blood vessels away from the wound have normal morphology (J:227170)

digestive/alimentary system
• mice display signs of illness in 3-4 days after the first tamoxifen injection which includes diarrhea

homeostasis/metabolism
• tamoxifen treated adults develop arteriovenous malformations around the ear-tag wound (J:212952)
• areas of wounds in mid-dorsum and ear of tamoxifen-injected mice show dilated and torturous vessels and the presence of arteriovenous (AV) shunts (J:227170)
• however, blood vessels away from the wound have normal morphology (J:227170)
• mice display signs of illness in 3-4 days after the first tamoxifen injection which includes dehydration

mortality/aging
• mice die around day 4-10 after the first tamoxifen treatment


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory