Phenotypes Associated with This Genotype

Genotype
MGI:5774703

• Allelic Composition: Cyfip2^{tm1(KOMP)Vlcg}/Cyfip2⁺; Fmr1^tm1Cgr/Y
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal anxiety-related response ( J:219363 )

♂ • increased transition between light and dark areas in a light-dark box assay that is more so than in single mutants with more time spent in the light area

decreased startle reflex ( J:219363 )

♂

hyperactivity ( J:219363 )

♂ • aggravated compared with Fmr1^tm1Cgr males

increased stereotypic behavior ( J:219363 )

♂

nervous system

abnormal dendritic spine morphology ( J:219363 )

♂ • hippocampal neurons exhibit increased density of think (immature) spines compared with wild-type neurons to the same extent as in Fmr1^tm1Cgr males

♂ • cortical neurons exhibit increased density of think (immature) spines compared with wild-type neurons to the same a greater extent than in Fmr1^tm1Cgr males

increased prepulse inhibition ( J:219363 )

♂