Phenotypes for Cyfip2 MGI:5774702 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cyfip2^{tm1(KOMP)Vlcg}/Cyfip2⁺
Genetic Background	involves: C57BL/6J * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyfip2^{tm1(KOMP)Vlcg} mutation (0 available); any Cyfip2 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal anxiety-related response ( J:219363 )

• increased transition between light and dark areas in a light-dark box assay

decreased startle reflex ( J:219363 )

hyperactivity ( J:219363 )

nervous system

nervous system phenotype ( J:219363 )

N	• mice exhibit normal hippocampal synaptic plasticity

abnormal dendritic spine morphology ( J:219363 )

• increased number of mature spines and total protrusions in cortical neurons

• DHPG-treated cortical neurons fail to exhibit a decrease in the number of mature spines and an increased average length of dendritic protrusions unlike in wild-type cortical neurons

increased prepulse inhibition ( J:219363 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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