Phenotypes for Cog6 MGI:5767608 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Cog6^{tm1a(EUCOMM)Wtsi}/Cog6^{tm1a(EUCOMM)Wtsi}
Genetic Background	C57BL/6N-Cog6^{tm1a(EUCOMM)Wtsi}/Wtsi
Cell Lines	EPD0609_4_H05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cog6^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Cog6 mutation (38 available)

Data Sources

IMPC Data for Cog6

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal vertebral artery topology ( J:239583 )

DMDD

abnormal liver vasculature morphology ( J:239583 )

DMDD

abnormal vitelline vein connection ( J:239583 )

DMDD

abnormal ductus venosus valve morphology ( J:239583 )

DMDD

abnormal inferior vena cava morphology ( J:239583 )

DMDD

dual inferior vena cava ( J:239583 )

DMDD

abnormal coronary sinus connection ( J:239583 )

DMDD

abnormal inferior vena cava valve morphology ( J:239583 )

DMDD

muscular ventricular septal defect ( J:239583 )

DMDD

intracerebral hemorrhage ( J:239583 )

DMDD

embryo

abnormal vitelline vein connection ( J:239583 )

DMDD

hematopoietic system

decreased transitional stage T2 B cell number ( J:211773 )

IMPC - WTSI

decreased erythrocyte cell number ( J:211773 )

IMPC - WTSI

decreased hematocrit ( J:211773 )

IMPC - WTSI

decreased hemoglobin content ( J:211773 )

IMPC - WTSI

decreased mean corpuscular hemoglobin ( J:211773 )

IMPC - WTSI

decreased mean corpuscular hemoglobin concentration ( J:211773 )

IMPC - WTSI

increased red blood cell distribution width ( J:211773 )

IMPC - WTSI

increased mean platelet volume ( J:211773 )

IMPC - WTSI

decreased marginal zone B cell number ( J:211773 )

IMPC - WTSI

decreased NK cell number ( J:211773 )

IMPC - WTSI

decreased Ly6C-positive immature NK cell number ( J:211773 )

IMPC - WTSI

decreased Ly6C-positive mature NK cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker NK cell number ( J:211773 )

IMPC - WTSI

decreased CD8-positive, naive alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive T-helper cell number ( J:211773 )

IMPC - WTSI

increased effector memory T-helper cell number ( J:211773 )

IMPC - WTSI

decreased T cell number ( J:211773 )

IMPC - WTSI

decreased NK T cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

decreased CD4-positive NK T cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker CD4-positive NK T cell number ( J:211773 )

IMPC - WTSI

decreased alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased T-helper cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased leukocyte cell number ( J:211773 )

IMPC - WTSI

increased granulocyte number ( J:211773 )

IMPC - WTSI

increased eosinophil cell number ( J:211773 )

IMPC - WTSI

increased B-2 B cell number ( J:211773 )

IMPC - WTSI

increased follicular B cell number ( J:211773 )

IMPC - WTSI

increased plasma cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive NK cell number ( J:211773 )

IMPC - WTSI

increased memory-marker NK cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta memory T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1+ CD4 alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1+ CD8 alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

increased gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased CD5-positive gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased memory-marker gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased monocyte cell number ( J:211773 )

IMPC - WTSI

increased Ly6C high monocyte number ( J:211773 )

IMPC - WTSI

homeostasis/metabolism

increased circulating bilirubin level ( J:211773 )

IMPC - WTSI

increased circulating alkaline phosphatase level ( J:211773 )

IMPC - WTSI

increased circulating amylase level ( J:211773 )

IMPC - WTSI

increased circulating aspartate transaminase level ( J:211773 )

IMPC - WTSI

increased circulating total protein level ( J:211773 )

IMPC - WTSI

immune system

decreased transitional stage T2 B cell number ( J:211773 )

IMPC - WTSI

decreased marginal zone B cell number ( J:211773 )

IMPC - WTSI

decreased NK cell number ( J:211773 )

IMPC - WTSI

decreased Ly6C-positive immature NK cell number ( J:211773 )

IMPC - WTSI

decreased Ly6C-positive mature NK cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker NK cell number ( J:211773 )

IMPC - WTSI

decreased CD8-positive, naive alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive T-helper cell number ( J:211773 )

IMPC - WTSI

increased effector memory T-helper cell number ( J:211773 )

IMPC - WTSI

decreased T cell number ( J:211773 )

IMPC - WTSI

decreased NK T cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

decreased CD4-positive NK T cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker CD4-positive NK T cell number ( J:211773 )

IMPC - WTSI

decreased alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased T-helper cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased leukocyte cell number ( J:211773 )

IMPC - WTSI

increased granulocyte number ( J:211773 )

IMPC - WTSI

increased eosinophil cell number ( J:211773 )

IMPC - WTSI

increased B-2 B cell number ( J:211773 )

IMPC - WTSI

increased follicular B cell number ( J:211773 )

IMPC - WTSI

increased plasma cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive NK cell number ( J:211773 )

IMPC - WTSI

increased memory-marker NK cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta memory T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1+ CD4 alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1+ CD8 alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

increased gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased CD5-positive gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased memory-marker gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased monocyte cell number ( J:211773 )

IMPC - WTSI

increased Ly6C high monocyte number ( J:211773 )

IMPC - WTSI

increased anti-nuclear antigen antibody level ( J:211773 )

IMPC - WTSI

integument

abnormal coat/hair pigmentation ( J:211773 )

IMPC - WTSI

liver/biliary system

abnormal liver vasculature morphology ( J:239583 )

DMDD

nervous system

intracerebral hemorrhage ( J:239583 )

DMDD

thin hypoglossal nerve ( J:239583 )

DMDD

normal phenotype

no abnormal phenotype detected ( J:239583 )

DMDD

pigmentation

abnormal coat/hair pigmentation ( J:211773 )

IMPC - WTSI

skeleton

fusion of vertebral arches ( J:239583 )

DMDD

vertebral transformation ( J:211773 )

IMPC - WTSI

abnormal bone structure ( J:211773 )

IMPC - WTSI

decreased bone mineral content ( J:211773 )

IMPC - WTSI

vision/eye

abnormal cornea morphology ( J:211773 )

IMPC - WTSI

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 01/13/2026 MGI 6.24