Phenotypes Associated with This Genotype

Genotype
MGI:5763275

• Allelic Composition: Tg(RNU6-RNAi:Rhox3)2Wilk/0; Tg(Stra8-icre)1Reb/0
• Genetic Background: involves: FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal spermatid morphology ( J:229199 )

♂ • abnormal of elongated spermatids

decreased male germ cell number ( J:229199 )

♂

oligozoospermia ( J:229199 )

♂ • few sperm in the cauda epididymides (greater than 100 fold reduction)

abnormal male meiosis ( J:229199 )

♂ • defective meiotic prophase

increased male germ cell apoptosis ( J:229199 )

♂ • of pachytene spermatocyte in seminiferous epithelial cycle stage IV

♂ • of spermatocytes undergoing meiotic metaphase in stage XII

♂ • of abnormal elongated spermatids

small seminiferous tubules ( J:229199 )

♂ • decreased diameter

decreased testis weight ( J:229199 )

♂ • however, seminal vesicle weight is normal

male infertility ( J:229199 )

♂

cellular

abnormal spermatid morphology ( J:229199 )

♂ • abnormal of elongated spermatids

decreased male germ cell number ( J:229199 )

♂

oligozoospermia ( J:229199 )

♂ • few sperm in the cauda epididymides (greater than 100 fold reduction)

abnormal male meiosis ( J:229199 )

♂ • defective meiotic prophase

increased male germ cell apoptosis ( J:229199 )

♂ • of pachytene spermatocyte in seminiferous epithelial cycle stage IV

♂ • of spermatocytes undergoing meiotic metaphase in stage XII

♂ • of abnormal elongated spermatids

endocrine/exocrine glands

small seminiferous tubules ( J:229199 )

♂ • decreased diameter

decreased testis weight ( J:229199 )

♂ • however, seminal vesicle weight is normal