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Phenotypes Associated with This Genotype
Genotype
MGI:5762957
Allelic
Composition
YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
Genetic
Background
either: B6.129S5-YwhazGt(OST432062)Lex or C.129S5-YwhazGt(OST432062)Lex or (involves: 129S5/SvEvBrd * 129T2/SvEmsWehi))
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
YwhazGt(OST432062)Lex mutation (3 available); any Ywhaz mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some mice die by P21
• however, mice that survive exhibit normal life expectancy

nervous system
N
• mice exhibit normal prefrontal cortex, cingulate cortex, amygdala, thalamus, nucleus accumbens, motor cortex and neuronal viability
• failure of neurons to migrate from their birthplace or to stop within their correct layer
• infrapyramidal mossy fibre tract are misrouted amongst the CA3 neurons compared to in wild-type mice
• misrouted axons form aberrant synapses within the stratum pyramidale
• disrupted organization
• split in to a bilaminar stratum
• in the stratum radiatum and stratum oriens
• in the superficial layer of CA3
• pyramidal neurons exhibit dendrites with thorny excrescences from the misrouted mossy fibre tracts on both proximal and distal apical dendrites compared with wild-type cells
• however, the number of branch points is normal

behavior/neurological
N
• mice exhibit normal sensorimotor abilities (olfaction, vision, balance and self-righting, eye blink, ear twitch, whisker-orientation and neuromuscular strength) and rearing
• in a cross-maze, mice exhibit increased latency in reaching the escape platform over the course of the acquisition period, decreased arm choice accuracy and increased escape latency compared with wild-type mice
• in an elevated plus maze, mice spend more time in open arms and enter them more often with increased head dips and fewer stretched attend postures compared with wild-type mice
• impaired novel object recognition when presented with a familiar and new object
• increased distance traveled in an open field in male and female mice
• hyperactivity in the object recognition test with longer exploration time in both phases of the trial
• increased activity in an elevated plus maze

growth/size/body
• from P14 onward

cellular
• failure of neurons to migrate from their birthplace or to stop within their correct layer

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
schizophrenia DOID:5419 OMIM:181500
J:217297


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/19/2019
MGI 6.13
The Jackson Laboratory