Phenotypes Associated with This Genotype

Genotype
MGI:5762832

• Allelic Composition: Hr^hr/Hr^hr; Tg(CD2-Stat6*V625A*T626A)78Mhk/0
• Genetic Background: involves: C3H * SKH1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

increased corneal pannus formation ( J:230018 )

• corneal disease (neovascular pannus formation) is seen

eye inflammation ( J:230018 )

• keratitis is seen in 35% of mice by 20 weeks of age

blepharitis ( J:230018 )

• infiltration of a mixed inflammatory cell infiltrate in the dermis of both the upper and lower eyelids

• a lymphocyte-predominant infiltrate containing variable numbers of eosinophils, macrophages, and neutrophils are seen in the substantia propria of the eyelids

• treatment of eyelids with clobetasol reverses blepharitis

Meibomian gland inflammation ( J:230018 )

• inflammatory infiltrate is seen in the Meibomian glands

uveitis ( J:230018 )

• uveitis, with inflammatory exudates in the anterior chamber of the eye

abnormal cornea morphology ( J:230018 )

• cornea exhibits keratinization of the epithelial layer, increased stromal inflammatory cells, neovascularization and corneal edema

• proteinous exudates with cellular infiltrates are seen along with erosion of the Descemente's membrane

abnormal eyelid morphology ( J:230018 )

• eyelid erythema evident as early as 7 weeks of age

• Th2 cytokine expression is increased in eyelids, indicating allergic inflammation

loss of eyelid cilia ( J:230018 )

• excoriations and madarosis evident as early as 7 weeks of age

immune system

increased corneal pannus formation ( J:230018 )

• corneal disease (neovascular pannus formation) is seen

eye inflammation ( J:230018 )

• keratitis is seen in 35% of mice by 20 weeks of age

blepharitis ( J:230018 )

• infiltration of a mixed inflammatory cell infiltrate in the dermis of both the upper and lower eyelids

• a lymphocyte-predominant infiltrate containing variable numbers of eosinophils, macrophages, and neutrophils are seen in the substantia propria of the eyelids

• treatment of eyelids with clobetasol reverses blepharitis

Meibomian gland inflammation ( J:230018 )

• inflammatory infiltrate is seen in the Meibomian glands

uveitis ( J:230018 )

• uveitis, with inflammatory exudates in the anterior chamber of the eye

cardiovascular system

abnormal physiological neovascularization ( J:230018 )

• peripheral neovascularization of the cornea, which extends centrally

endocrine/exocrine glands

Meibomian gland inflammation ( J:230018 )

• inflammatory infiltrate is seen in the Meibomian glands

homeostasis/metabolism

edema ( J:230018 )

• periocular edema evident as early as 7 weeks of age

integument

Meibomian gland inflammation ( J:230018 )

• inflammatory infiltrate is seen in the Meibomian glands

loss of eyelid cilia ( J:230018 )

• excoriations and madarosis evident as early as 7 weeks of age